Sex Hormone Binding Globulin (SHBG)

Sex Hormone Binding Globulin (SHBG) levels are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children. This test is used to evaluate whether the concentration of sex hormone binding globulin (SHBG) is affecting the amount of testosterone available to the body’s tissues This is a non-fasting test that results in 2-3 business days.

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